Original Article

Alcohol consumption and risk for stroke among Chinese men

  1. Lydia A. Bazzano MD, PhD1,2,*,
  2. Dongfeng Gu MD3,
  3. Kristi Reynolds PhD1,
  4. Xiqui Wu MD3,
  5. Chiung-Shiuan Chen MS1,
  6. Xiufang Duan MD3,
  7. Jing Chen MD, MS2,
  8. Rachel P. Wildman PhD1,
  9. Michael J. Klag MD, MPH4,
  10. Jiang He MD, PhD1,2

Article first published online: 20 AUG 2007

DOI: 10.1002/ana.21194

Issue

Annals of Neurology

Annals of Neurology

Volume 62, Issue 6, pages 569–578, December 2007

Additional Information

How to Cite

Bazzano, L. A., Gu, D., Reynolds, K., Wu, X., Chen, C.-S., Duan, X., Chen, J., Wildman, R. P., Klag, M. J. and He, J. (2007), Alcohol consumption and risk for stroke among Chinese men. Annals of Neurology, 62: 569–578. doi: 10.1002/ana.21194

Author Information

  1. 1

    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA

  2. 2

    Department of Medicine, Tulane University School of Medicine, New Orleans, LA

  3. 3

    The Cardiovascular Institute and Fu Wai Hospital of the Chinese Academy of Medical Sciences and Peking Union Medical College, and National Center for Cardiovascular Disease Control and Research, Beijing, China

  4. 4

    Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD

*Departments of Epidemiology and Medicine, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, SL-18, New Orleans, LA 70112-2715

Publication History

  1. Issue published online: 27 DEC 2007
  2. Article first published online: 20 AUG 2007
  3. Manuscript Accepted: 15 JUN 2007
  4. Manuscript Revised: 22 MAY 2007
  5. Manuscript Received: 11 JAN 2007

Funded by

  • Building Interdisciplinary Research Careers in Women's Health Scholarship. Grant Number: K12-HD43451
  • Office of Research on Women's Health (ORWH)
  • Office of Dietary Supplements (ODS) of the NIH
  • NIH (National Center for Research Resources). Grant Number: P20-RR17659

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Abstract

Objective

Stroke is a leading cause of death and long-term disability in China. The objective of this study was to examine the relation between alcohol consumption and risk for stroke among Chinese men.

Methods

We conducted a prospective cohort study among 64,338 Chinese men aged ≥40 years who were free of stroke at baseline. Data on frequency and type of alcohol consumed were collected at the baseline examination in 1991 using a standard protocol. Follow-up evaluation was conducted in 1999 to 2000, which included determining vital status, interviewing participants or proxies, and obtaining hospital and medical records for incident and fatal strokes.

Results

Over the course of 493,351 person-years of follow-up, we documented 3,434 incident strokes (1,848 stroke deaths). After adjustment for age, body mass index, physical activity, urbanization (urban vs rural), geographic variation (north vs south), cigarette smoking, history of diabetes, and education, compared with nondrinkers, relative risk (95% confidence interval) of incident stroke was 0.92 (0.80–1.06) for participants consuming 1 to 6 drinks/week, 1.02 (0.93–1.13) for those consuming 7 to 20 drinks/week, 1.22 (1.07–1.38) for those consuming 21 to 34 drinks/week, and 1.22 (1.08–1.37) for those consuming 35 or more drinks per week (p for linear trend < 0.0001). The corresponding relative risks for stroke mortality were 0.93 (0.76–1.14), 0.98 (0.85–1.13), 1.15 (0.95–1.38), and 1.30 (1.11–1.52), respectively (p for linear trend = 0.0004; p for quadratic trend = 0.03).

Interpretation

These results suggest that heavy alcohol drinking may increase the risk for stroke in Chinese men and should be the target of strategies for prevention. Ann Neurol 2007

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