Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease
Version of Record online: 19 NOV 2007
Copyright © 2007 American Neurological Association
Annals of Neurology
Volume 63, Issue 1, pages 112–118, January 2008
How to Cite
Kemppainen, N. M., Aalto, S., Karrasch, M., Någren, K., Savisto, N., Oikonen, V., Viitanen, M., Parkkola, R. and Rinne, J. O. (2008), Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease. Ann Neurol., 63: 112–118. doi: 10.1002/ana.21212
- Issue online: 29 JAN 2008
- Version of Record online: 19 NOV 2007
- Manuscript Accepted: 16 JUL 2007
- Manuscript Revised: 14 JUN 2007
- Manuscript Received: 8 APR 2007
- Turku University Hospital
- Maud Kuistila Foundation
- Sigrid Juselius Foundation
- Research Council for Health of the Academy of Finland. Grant Number: project #205954
The reduced risk for Alzheimer's disease (AD) in high-educated individuals has been proposed to reflect brain cognitive reserve, which would provide more efficient compensatory mechanisms against the underlying pathology, and thus delayed clinical expression. Our aim was to find possible differences in brain amyloid ligand 11C-labeled Pittsburgh Compound B ([11C]PIB) uptake and glucose metabolism in high- and low-educated patients with mild AD.
Twelve high-educated and 13 low-educated patients with the same degree of cognitive deterioration were studied with PET using [11C]PIB and 18F-fluorodeoxyglucose as ligands. The between-group differences were analyzed with voxel-based statistical method, and quantitative data were obtained with automated region-of-interest analysis.
High-educated patients showed increased [11C]PIB uptake in the lateral frontal cortex compared with low-educated patients. Moreover, high-educated patients had significantly lower glucose metabolic rate in the temporoparietal cortical regions compared with low-educated patients.
Our results suggesting more advanced pathological and functional brain changes in high-educated patients with mild AD are in accordance with the brain cognitive reserve hypothesis and point out the importance of development of reliable markers of underlying AD pathology for early AD diagnostics. Ann Neurol 2007