Get access

Association of olfactory dysfunction with risk for future Parkinson's disease

Authors

  • G. Webster Ross MD,

    Corresponding author
    1. Veterans Affairs Pacific Islands Health Care System, University of Hawaii John A. Burns School of Medicine, Honolulu, HI
    2. Departments of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, HI
    3. Departments of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, HI
    4. Pacific Health Research Institute, Honolulu, HI
    5. Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI
    • VA Pacific Islands Health Care System, 459 Patterson Road, Honolulu, HI 96819
    Search for more papers by this author
  • Helen Petrovitch MD,

    1. Veterans Affairs Pacific Islands Health Care System, University of Hawaii John A. Burns School of Medicine, Honolulu, HI
    2. Departments of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, HI
    3. Departments of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, HI
    4. Pacific Health Research Institute, Honolulu, HI
    5. Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI
    Search for more papers by this author
  • Robert D. Abbott PhD,

    1. Pacific Health Research Institute, Honolulu, HI
    2. Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI
    3. Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, VA
    4. Department of Health Sciences, Shiga University of Medical Science, Otsu, Japan
    5. Japan Society for the Promotion of Science, Tokyo, Japan
    Search for more papers by this author
  • Caroline M. Tanner MD, PhD,

    1. The Parkinson's Institute, Sunnyvale, CA
    Search for more papers by this author
  • Jordan Popper MD,

    1. Veterans Affairs Pacific Islands Health Care System, University of Hawaii John A. Burns School of Medicine, Honolulu, HI
    2. Departments of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, HI
    Search for more papers by this author
  • Kamal Masaki MD,

    1. Departments of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, HI
    2. Pacific Health Research Institute, Honolulu, HI
    3. Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI
    Search for more papers by this author
  • Lenore Launer PhD,

    1. National Institute on Aging, National Institutes of Health, Bethesda, MD
    Search for more papers by this author
  • Lon R. White MD, MPH

    1. Veterans Affairs Pacific Islands Health Care System, University of Hawaii John A. Burns School of Medicine, Honolulu, HI
    2. Departments of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, HI
    3. Departments of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, HI
    4. Pacific Health Research Institute, Honolulu, HI
    5. Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI
    Search for more papers by this author

Abstract

Objective

Although olfactory dysfunction is commonly associated with Parkinson's disease (PD), it is not known whether such dysfunction can predate the onset of clinical PD in a community-based population. This study examines the association of olfactory dysfunction with future development of PD in Honolulu-Asia Aging Study cohort members

Methods

Olfaction was assessed from 1991 to 1996 in 2,267 men in the Honolulu-Asia Aging Study aged 71 to 95 years who were free of clinical PD and dementia at the time of olfaction testing. Participants were followed for up to 8 years for incident PD

Results

In the course of follow-up, 35 men were diagnosed with PD (24.6/10,000 person-years). The average age at the time of diagnosis was 82.9 ± 3.8 (range, 76–93) years, and the average time to a diagnosis was 4.0 ± 1.9 (range, 1–8) years. During the first 4 years of follow-up, age-adjusted incidence of PD declined from 54.5/10,000 person-years in the lowest quartile of odor identification to 26.6, 8.2, and 8.4/10,000 person-years in the second, third, and fourth quartiles, respectively (p < 0.001 for trend). After adjustment for age and other potential confounders, the odds ratios for PD in the lowest quartile was 5.2 (95% confidence interval, 1.5–25.6) compared with the top two quartiles. This relation was not evident beyond 4 years of follow-up

Interpretation

Impaired olfaction can predate clinical PD in men by at least 4 years and may be a useful screening tool to detect those at high risk for development of PD in later life. Ann Neurol 2007

Get access to the full text of this article

Ancillary