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Memory enhancement induced by hypothalamic/fornix deep brain stimulation

  1. Clement Hamani MD, PhD1,
  2. Mary Pat McAndrews PhD2,
  3. Melanie Cohn PhD2,
  4. Michael Oh MD1,
  5. Dominik Zumsteg MD3,
  6. Colin M. Shapiro MD, PhD, FRCPC4,
  7. Richard A. Wennberg MD, FRCPC3,
  8. Andres M. Lozano MD, PhD, FRCSC1,*

Article first published online: 29 JAN 2008

DOI: 10.1002/ana.21295

Issue

Annals of Neurology

Annals of Neurology

Volume 63, Issue 1, pages 119–123, January 2008

Additional Information

How to Cite

Hamani, C., McAndrews, M. P., Cohn, M., Oh, M., Zumsteg, D., Shapiro, C. M., Wennberg, R. A. and Lozano, A. M. (2008), Memory enhancement induced by hypothalamic/fornix deep brain stimulation. Ann Neurol., 63: 119–123. doi: 10.1002/ana.21295

Author Information

  1. 1

    Division of Neurosurgery, Toronto Western Hospital and Research Institute, University of Toronto, Toronto, Ontario, Canada

  2. 2

    Division of Psychology, Toronto Western Hospital and Research Institute, University of Toronto, Toronto, Ontario, Canada

  3. 3

    Division of Neurology, Toronto Western Hospital and Research Institute, University of Toronto, Toronto, Ontario, Canada

  4. 4

    Division of Psychiatry, Toronto Western Hospital and Research Institute, University of Toronto, Toronto, Ontario, Canada

*Division of Neurosurgery, Toronto Western Hospital, West Wing 4-447, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada

Publication History

  1. Issue published online: 29 JAN 2008
  2. Article first published online: 29 JAN 2008
  3. Manuscript Accepted: 4 OCT 2007
  4. Manuscript Revised: 31 AUG 2007
  5. Manuscript Received: 5 JUL 2007

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Abstract

Bilateral hypothalamic deep brain stimulation was performed to treat a patient with morbid obesity. We observed, quite unexpectedly, that stimulation evoked detailed autobiographical memories. Associative memory tasks conducted in a double-blinded “on” versus “off” manner demonstrated that stimulation increased recollection but not familiarity-based recognition, indicating a functional engagement of the hippocampus. Electroencephalographic source localization showed that hypothalamic deep brain stimulation drove activity in mesial temporal lobe structures. This shows that hypothalamic stimulation in this patient modulates limbic activity and improves certain memory functions. Ann Neurol 2008;63:119–123

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