Memory enhancement induced by hypothalamic/fornix deep brain stimulation

Authors

  • Clement Hamani MD, PhD,

    1. Division of Neurosurgery, Toronto Western Hospital and Research Institute, University of Toronto, Toronto, Ontario, Canada
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  • Mary Pat McAndrews PhD,

    1. Division of Psychology, Toronto Western Hospital and Research Institute, University of Toronto, Toronto, Ontario, Canada
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  • Melanie Cohn PhD,

    1. Division of Psychology, Toronto Western Hospital and Research Institute, University of Toronto, Toronto, Ontario, Canada
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  • Michael Oh MD,

    1. Division of Neurosurgery, Toronto Western Hospital and Research Institute, University of Toronto, Toronto, Ontario, Canada
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  • Dominik Zumsteg MD,

    1. Division of Neurology, Toronto Western Hospital and Research Institute, University of Toronto, Toronto, Ontario, Canada
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  • Colin M. Shapiro MD, PhD, FRCPC,

    1. Division of Psychiatry, Toronto Western Hospital and Research Institute, University of Toronto, Toronto, Ontario, Canada
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  • Richard A. Wennberg MD, FRCPC,

    1. Division of Neurology, Toronto Western Hospital and Research Institute, University of Toronto, Toronto, Ontario, Canada
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  • Andres M. Lozano MD, PhD, FRCSC

    Corresponding author
    1. Division of Neurosurgery, Toronto Western Hospital and Research Institute, University of Toronto, Toronto, Ontario, Canada
    • Division of Neurosurgery, Toronto Western Hospital, West Wing 4-447, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada
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Abstract

Bilateral hypothalamic deep brain stimulation was performed to treat a patient with morbid obesity. We observed, quite unexpectedly, that stimulation evoked detailed autobiographical memories. Associative memory tasks conducted in a double-blinded “on” versus “off” manner demonstrated that stimulation increased recollection but not familiarity-based recognition, indicating a functional engagement of the hippocampus. Electroencephalographic source localization showed that hypothalamic deep brain stimulation drove activity in mesial temporal lobe structures. This shows that hypothalamic stimulation in this patient modulates limbic activity and improves certain memory functions. Ann Neurol 2008;63:119–123

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