Potential conflict of interest: Nothing to report.
COL4A1 mutation in two preterm siblings with antenatal onset of parenchymal hemorrhage†
Article first published online: 4 FEB 2009
Copyright © 2009 American Neurological Association
Annals of Neurology
Volume 65, Issue 1, pages 12–18, January 2009
How to Cite
de Vries, L. S., Koopman, C., Groenendaal, F., Van Schooneveld, M., Verheijen, F. W., Verbeek, E., Witkamp, T. D., van der Worp, H. B. and Mancini, G. (2009), COL4A1 mutation in two preterm siblings with antenatal onset of parenchymal hemorrhage. Ann Neurol., 65: 12–18. doi: 10.1002/ana.21525
- Issue published online: 12 FEB 2009
- Article first published online: 4 FEB 2009
- Manuscript Accepted: 15 AUG 2008
- Manuscript Revised: 3 AUG 2008
- Manuscript Received: 3 JUL 2008
To report the presence of intracerebral hemorrhage and porencephaly, both present at birth, in two preterm infants with a mutation in the collagen 4 A1 gene.
Two preterm infants with antenatal intracerebral hemorrhage and established porencephaly, as well as their affected mother and grandfather, underwent neurological and ophthalmological examination and magnetic resonance imaging of the brain. Mutation analysis of the COL4A1 gene was performed in the infants and in their mother.
Both infants had a novel G1580R mutation in the COL4A1 gene, encoding procollagen type IV α1. A history of mild antenatal trauma was present in the first but not in the second infant. Both preterm infants were asymptomatic at birth. The intracerebral hemorrhage and porencephaly were diagnosed with cranial ultrasound examination and were subsequently confirmed with magnetic resonance imaging. Leukoencephalopathy was present in the mother and in her father.
Mutation of the COL4A1 gene appears to be a risk factor of antenatal intracerebral hemorrhage followed by porencephaly in the preterm newborn. Ann Neurol 2009;65:12–18