Additional Supporting Information may be found in the online version of this article.

ANA_21719_sm_SupFig1.tif2363KSupplementary Fig 1. Histomorphometric parameters of myelinated nerve fibers in the sciatic nerve. Axonal density of myelinated nerve fibers is significant lower in active experimental autoimmune encephalomyelitis (EAE) animals (n = 5) than in controls (C; n = 4). Morphometric analysis does not reveal significant differences between myelinated fibers of the sciatic nerve in control animals and in active EAE animals. Error bars indicate standard error of the mean. *p < 0.05.
ANA_21719_sm_SupFig2.tif2148KSupplementary Fig 2. Axonal injury around α-motor neurons revealed by APP-staining. (A) Photomicrographs of the ventral horn of the spinal cord show APP-positive ovoids at the different investigated disease stages. Scale bar: 50μm. (B) Higher magnification of the lamina 9 shows APP signal (arrows) around the α-motor neurons. Scale bar: 12.5μm. PLP = proteolipid protein.
ANA_21719_sm_SupDoc.doc259KSupplementary Material
ANA_21719_sm_SupTab.doc103KSupplementary Table 1. Donor Characteristics for Human Spinal Cord Analysis. Supplementary Table 2: Donor Characteristics for Human Cortex Analysis. Supplementary Table 3. Stereology Data for Human Spinal Cord Neuron Analysis. Supplementary Table 4. Stereology Data for EAE Spinal Cord Neuron Analysis. Supplementary Table 5. Stereology Data for TRAIL−/− EAE Spinal Cord Neuron Analysis. Supplementary Table 6. Stereology Data for EAE Spinal Cord Immune Infiltration Analysis. Supplementary Table 7. Stereology Data for APP Ovoids in Layer 9 and Myelinated Axons in the Sciatic Nerve.

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