Authors share first authorship.
Lower motor neuron loss in multiple sclerosis and experimental autoimmune encephalomyelitis†
Version of Record online: 13 APR 2009
Copyright © 2009 American Neurological Association
Annals of Neurology
Volume 66, Issue 3, pages 310–322, September 2009
How to Cite
Vogt, J., Paul, F., Aktas, O., Müller-Wielsch, K., Dörr, J., Dörr, S., Bharathi, B. S., Glumm, R., Schmitz, C., Steinbusch, H., Raine, C. S., Tsokos, M., Nitsch, R. and Zipp, F. (2009), Lower motor neuron loss in multiple sclerosis and experimental autoimmune encephalomyelitis. Ann Neurol., 66: 310–322. doi: 10.1002/ana.21719
Potential conflict of interest: Nothing to report.
- Issue online: 1 OCT 2009
- Version of Record online: 13 APR 2009
- Accepted manuscript online: 13 APR 2009 12:00AM EST
- Manuscript Accepted: 23 MAR 2009
- Manuscript Revised: 3 MAR 2009
- Manuscript Received: 9 DEC 2008
- Institute for Multiple Sclerosis Research (IMSF)
- Göttingen/Hertie Foundation
- German Research Foundation. Grant Numbers: DFG: SFB 507, SFB-TRR 43, SFB 650
- German Ministry of Education and Research
- European Union. Grant Numbers: EU5FP, QLK6-CT-2000-60042-44, QLK6-GH-00-60042-44, NMSS 1001-K-1, NS 08952, NS 11920
Additional Supporting Information may be found in the online version of this article.
|ANA_21719_sm_SupFig1.tif||2363K||Supplementary Fig 1. Histomorphometric parameters of myelinated nerve fibers in the sciatic nerve. Axonal density of myelinated nerve fibers is significant lower in active experimental autoimmune encephalomyelitis (EAE) animals (n = 5) than in controls (C; n = 4). Morphometric analysis does not reveal significant differences between myelinated fibers of the sciatic nerve in control animals and in active EAE animals. Error bars indicate standard error of the mean. *p < 0.05.|
|ANA_21719_sm_SupFig2.tif||2148K||Supplementary Fig 2. Axonal injury around α-motor neurons revealed by APP-staining. (A) Photomicrographs of the ventral horn of the spinal cord show APP-positive ovoids at the different investigated disease stages. Scale bar: 50μm. (B) Higher magnification of the lamina 9 shows APP signal (arrows) around the α-motor neurons. Scale bar: 12.5μm. PLP = proteolipid protein.|
|ANA_21719_sm_SupTab.doc||103K||Supplementary Table 1. Donor Characteristics for Human Spinal Cord Analysis. Supplementary Table 2: Donor Characteristics for Human Cortex Analysis. Supplementary Table 3. Stereology Data for Human Spinal Cord Neuron Analysis. Supplementary Table 4. Stereology Data for EAE Spinal Cord Neuron Analysis. Supplementary Table 5. Stereology Data for TRAIL−/− EAE Spinal Cord Neuron Analysis. Supplementary Table 6. Stereology Data for EAE Spinal Cord Immune Infiltration Analysis. Supplementary Table 7. Stereology Data for APP Ovoids in Layer 9 and Myelinated Axons in the Sciatic Nerve.|
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