Developmental plasticity connects visual cortex to motoneurons after stroke

Authors

  • Anna Basu BM, BCh, PhD,

    1. Developmental Neuroscience, Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK
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  • Sara Graziadio PhD,

    1. Developmental Neuroscience, Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK
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  • Martin Smith MB, BS, PhD,

    1. Oswestry and Birmingham Children's Hospital, Birmingham, UK
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  • Gavin J. Clowry DPhil,

    1. Developmental Neuroscience, Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK
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  • Giovanni Cioni MD,

    1. Division of Child Neurology and Psychiatry, University of Pisa, Pisa, Italy and Department of Developmental Neuroscience, Stella Maris Scientific Institute, Pisa, Italy
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  • Janet A. Eyre MB, ChB, DPhil

    Corresponding author
    1. Developmental Neuroscience, Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK
    • Developmental Neuroscience, Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Queen Victoria Road, Newcastle Upon Tyne, NE1 4LP, United Kingdom
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Abstract

We report motor cortical function in the left occipital cortex of a subject who suffered a left middle cerebral artery stroke early in development. Transcranial magnetic stimulation of the left occipital cortex evoked contraction of right hand muscles. Electroencephalogram recorded over the left occipital cortex showed: 1) coherence with electromyogram from a right hand muscle; 2) a typical sensorimotor Mu rhythm at rest that was suppressed during contraction of right hand muscles. This is the first evidence that cortical plasticity extends beyond reshaping of primary sensory cortical fields to respecification of the cortical origin of subcortically projecting pathways. ANN NEUROL 2010;67:132–136

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