Original Article

You have free access to this content

Role of endogenous testosterone concentration in pediatric stroke†

  1. Sandra Normann MD1,
  2. Gabrielle de Veber MD2,
  3. Manfred Fobker MD3,
  4. Claus Langer PhD3,
  5. Gili Kenet MD4,
  6. Timothy J. Bernard MD5,6,
  7. Barbara Fiedler MD7,
  8. Ronald Sträter MD1,
  9. Neil A. Goldenberg MD, PhD5,6,
  10. Ulrike Nowak-Göttl MD1,*

Article first published online: 21 AUG 2009

DOI: 10.1002/ana.21840

Issue

Annals of Neurology

Annals of Neurology

Volume 66, Issue 6, pages 754–758, December 2009

Additional Information

How to Cite

Normann, S., de Veber, G., Fobker, M., Langer, C., Kenet, G., Bernard, T. J., Fiedler, B., Sträter, R., Goldenberg, N. A. and Nowak-Göttl, U. (2009), Role of endogenous testosterone concentration in pediatric stroke. Annals of Neurology, 66: 754–758. doi: 10.1002/ana.21840

Author Information

  1. 1

    Department of Pediatric Hematology/Oncology, University Children's Hospital, University of Münster, Münster,Germany

  2. 2

    Department of Neurology, Hospital for Sick Children, Toronto, Canada

  3. 3

    Department of Laboratory Medicine, University Hospital, Münster, Germany

  4. 4

    The Israel National Hemophilia Center, Sheba Medical Center, Tel-Hashomer, Israel

  5. 5

    The Mountain States Regional Hemophilia and Thrombosis Center, Department of Pediatrics, University of Colorado, Denver, CO

  6. 6

    The Children's Hospital, Aurora, CO

  7. 7

    Department of Pediatric Neurology, University Children's Hospital, Münster, Germany

*Pediatric Hematology/Oncology, University of Münster, Albert-Schweitzer-Str. 33, D-48149 Münster, Germany

  1. †

    Potential conflict of interest: Nothing to report.

Publication History

  1. Issue published online: 23 DEC 2009
  2. Article first published online: 21 AUG 2009
  3. Accepted manuscript online: 21 AUG 2009 12:00AM EST
  4. Manuscript Accepted: 11 AUG 2009
  5. Manuscript Revised: 1 AUG 2009
  6. Manuscript Received: 18 MAY 2009

Funded by

  • Surveillance Unit of Rare Pediatric Diseases in Germany (ESPED, Supplementary Material)
  • Karl-Bröcker-Stiftung
  • Stiftung Deutsche Schlaganfall-Hilfe
  • Pediatric Stroke and Thrombosis Foundation e.V.
  • Career Development Award from the National Institutes of Health
  • National Heart Lung and Blood Institute. Grant Number: 1K23HL084055-01A1
  • National Centers for Research Resources. Grant Number: KL2RR025779

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (87K)

Abstract

Previous studies have indicated a male predominance in pediatric stroke. To elucidate this gender disparity, total testosterone concentration was measured in children with arterial ischemic stroke (AIS; n = 72), children with cerebral sinovenous thrombosis (CSVT; n = 52), and 109 healthy controls. Testosterone levels above the 90th percentile for age and gender were documented in 10 children with AIS (13.9%) and 10 with CSVT (19.2%), totaling 16.7% of patients with cerebral thromboembolism overall, as compared with only 2 of 109 controls (1.8%; p = 0.002). In multivariate analysis with adjustment for total cholesterol level, hematocrit, and pubertal status, elevated testosterone was independently associated with increased disease risk (odds ratio [95% confidence interval]: overall = 3.98 [1.38–11.45]; AIS = 3.88 [1.13–13.35]; CSVT = 5.50 [1.65–18.32]). Further adjusted analyses revealed that, for each 1nmol/l increase in testosterone in boys, the odds of cerebral thromboembolism were increased 1.3-fold. Ann Neurol 2009;66:754–758

View Full Article (HTML) Get PDF (87K)