Original Article

APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

  1. John C. Morris MD1,2,3,4,5,*,
  2. Catherine M. Roe PhD1,2,
  3. Chengjie Xiong PhD1,6,
  4. Anne M. Fagan PhD1,2,
  5. Alison M. Goate PhD1,2,7,8,9,
  6. David M. Holtzman MD1,2,7,
  7. Mark A. Mintun MD1,10

Article first published online: 21 AUG 2009

DOI: 10.1002/ana.21843

Issue

Annals of Neurology

Annals of Neurology

Volume 67, Issue 1, pages 122–131, January 2010

Additional Information

How to Cite

Morris, J. C., Roe, C. M., Xiong, C., Fagan, A. M., Goate, A. M., Holtzman, D. M. and Mintun, M. A. (2010), APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Ann Neurol., 67: 122–131. doi: 10.1002/ana.21843

Author Information

  1. 1

    Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO

  2. 2

    Department of Neurology, Washington University School of Medicine, St. Louis, MO

  3. 3

    Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO

  4. 4

    Department of Physical Therapy, Washington University School of Medicine, St. Louis, MO

  5. 5

    Department of Occupational Therapy, Washington University School of Medicine, St. Louis, MO

  6. 6

    Division of Biostatistics, Washington University School of Medicine, St. Louis, MO

  7. 7

    Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO

  8. 8

    Department of Psychiatry, Washington University School of Medicine, St. Louis, MO

  9. 9

    Department of Genetics, Washington University School of Medicine, St. Louis, MO

  10. 10

    Department of Radiology, Washington University School of Medicine, St. Louis, MO

*Alzheimer Disease Research Center, 4488 Forest Park Avenue, Suite 160, St. Louis, MO 63108

Publication History

  1. Issue published online: 23 FEB 2010
  2. Article first published online: 21 AUG 2009
  3. Accepted manuscript online: 21 AUG 2009 12:00AM EST
  4. Manuscript Revised: 1 JUL 2009
  5. Manuscript Accepted: 1 JUL 2009
  6. Manuscript Received: 23 APR 2009

Funded by

  • National Institute on Aging. Grant Numbers: P50 AG05681, P01 AG03991, P01 AG026276
  • Charles and Joanne Knight Alzheimer Research Initiative of the Washington University Alzheimer's Disease Research Center, St. Louis, MO
  • National Center for Research Resources. Grant Number: Postdoctoral Program of 1UL1RR024992-01

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View Full Article with Supporting Information (HTML) Get PDF (326K)