Article first published online: 11 MAR 2010
Copyright © 2010 American Neurological Association
Annals of Neurology
Volume 67, Issue 2, page 277, February 2010
How to Cite
- Issue published online: 11 MAR 2010
- Article first published online: 11 MAR 2010
In Annals of Neurology, 38th Child Neurology Society Annual Meeting Program, p. 55, Poster #116 should appear as:
Unexplained neonatal encephalopathy: potential role of methylenetetrahydrofolate reductase polymorphisms.
Scalais E, Larcher M-E, Nuttin C, Gijzels C, Mataigne F, Weinacht M, De Meirleir L., Luxembourg and Brussels, Belgium.
Background: Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms are associated with lower MTHFR activity.
Objective: retrospective case-control evaluation of unexplained neonatal encephalopathy with reference to both C677T and A1298C as a genetic risk for this condition.
Method: Seven infants with unexplained encephalopathy, 42 healthy individuals and 7 infants with genetic disease were genotyped for MTHFR polymorphisms (C677T, A1298C). All studied infants had metabolic screening, early magnetic resonance imaging (MRI) and were followed between 6 months and 3 years.
Conclusion: The data presented here suggest that MTHFR polymorphisms play a potential role in unexplained neonatal encephalopathy.