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Venous and cerebrospinal fluid flow in multiple sclerosis: A case-control study

  1. Peter Sundström MD, PhD1,*,
  2. Anders Wåhlin MSc2,
  3. Khalid Ambarki MSc, PhD2,
  4. Richard Birgander MD, PhD2,
  5. Anders Eklund MSc, PhD2,3,4,
  6. Jan Malm MD, PhD1

Article first published online: 2 AUG 2010

DOI: 10.1002/ana.22132

Issue

Annals of Neurology

Annals of Neurology

Volume 68, Issue 2, pages 255–259, August 2010

Additional Information

How to Cite

Sundström, P., Wåhlin, A., Ambarki, K., Birgander, R., Eklund, A. and Malm, J. (2010), Venous and cerebrospinal fluid flow in multiple sclerosis: A case-control study. Ann Neurol., 68: 255–259. doi: 10.1002/ana.22132

Author Information

  1. 1

    Department of Clinical Neuroscience, Umeå, Sweden

  2. 2

    Department of Radiation Sciences, Umeå University, Umeå, Sweden

  3. 3

    Department of Biomedical Engineering and Informatics, Umeå University Hospital, Umeå, Sweden

  4. 4

    Center for Biomedical Engineering and Physics, Umeå University, Umeå, Sweden

*Department of Neurology, Umeå University Hospital, SE- 901 85 Umeå, Sweden

Publication History

  1. Issue published online: 2 AUG 2010
  2. Article first published online: 2 AUG 2010
  3. Manuscript Accepted: 17 JUN 2010
  4. Manuscript Revised: 4 JUN 2010
  5. Manuscript Received: 2 MAY 2010

Funded by

  • Swedish research council
  • Vinnova
  • Foundation for Strategic Research, through their joint initiative Biomedical Engineering for Better Health, and by the Objective 2 Norra Norrland–European Union Structural Fund

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Abstract

The prevailing view on multiple sclerosis etiopathogenesis has been challenged by the suggested new entity chronic cerebrospinal venous insufficiency. To test this hypothesis, we studied 21 relapsing-remitting multiple sclerosis cases and 20 healthy controls with phase-contrast magnetic resonance imaging. In addition, in multiple sclerosis cases we performed contrast-enhanced magnetic resonance angiography. We found no differences regarding internal jugular venous outflow, aqueductal cerebrospinal fluid flow, or the presence of internal jugular blood reflux. Three of 21 cases had internal jugular vein stenoses. In conclusion, we found no evidence confirming the suggested vascular multiple sclerosis hypothesis. ANN NEUROL 2010;68:255–259

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