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Ictal very low frequency oscillation in human epilepsy patients

Authors

  • Liankun Ren MD,

    1. Department of Neurology, China-Japan Friendship Hospital, Beijing, China
    2. Department of Neurology, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Aoi-ku, Shizuoka, Japan
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  • Kiyohito Terada MD,

    Corresponding author
    1. Department of Neurology, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Aoi-ku, Shizuoka, Japan
    • Department of Neurology, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, 886 Urushiyama, Aoi-ku, Shizuoka, 420-8688 Japan
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  • Koichi Baba MD,

    1. Department of Neurosurgery, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Aoi-ku, Shizuoka, Japan
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  • Naotaka Usui MD,

    1. Department of Neurosurgery, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Aoi-ku, Shizuoka, Japan
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  • Shuichi Umeoka MD,

    1. Department of Neurosurgery, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Aoi-ku, Shizuoka, Japan
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  • Keiko Usui MD,

    1. Department of Neurology, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Aoi-ku, Shizuoka, Japan
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  • Kazumi Matsuda MD,

    1. Department of Neurosurgery, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Aoi-ku, Shizuoka, Japan
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  • Takayasu Tottori MD,

    1. Department of Neurosurgery, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Aoi-ku, Shizuoka, Japan
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  • Fumihiro Nakamura MD,

    1. Department of Psychiatry, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Aoi-ku, Shizuoka, Japan
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  • Tadahiro Mihara MD,

    1. Department of Neurosurgery, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Aoi-ku, Shizuoka, Japan
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  • Yushi Inoue MD

    1. Department of Psychiatry, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Aoi-ku, Shizuoka, Japan
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Abstract

Using intracranial electroencephalographic recordings, we identified a distinct brain activity in 3 patients with refractory epilepsy characterized by very early occurrence from 8 minutes 10 seconds to 22 minutes 40 seconds prior to clinical seizure onset, periodical appearance of slow negative baseline shift, long interpeak interval of 40 to 120 seconds, and disappearance after clinical seizure. We named this activity “very low frequency oscillation” (VLFO), which reflected a dynamic process during the preictal state. This observation may render new insight into epileptogenesis and provide additional information concerning the epileptogenic zone as well as prediction of epileptic seizures. Ann Neurol 2010

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