Hypothalamic gray matter volume loss in hypnic headache
Article first published online: 8 NOV 2010
Copyright © 2010 American Neurological Association
Annals of Neurology
Volume 69, Issue 3, pages 533–539, March 2011
How to Cite
Holle, D., Naegel, S., Krebs, S., Gaul, C., Gizewski, E., Diener, H.-C., Katsarava, Z. and Obermann, M. (2011), Hypothalamic gray matter volume loss in hypnic headache. Ann Neurol., 69: 533–539. doi: 10.1002/ana.22188
- Issue published online: 28 MAR 2011
- Article first published online: 8 NOV 2010
- Manuscript Accepted: 30 JUL 2010
- Manuscript Revised: 25 JUL 2010
- Manuscript Received: 12 MAY 2010
Hypnic headache (HH) is a rare primary headache disorder characterized by strictly nocturnal headache attacks that mostly occur at the same time at night. The pathophysiology of this disease is poorly understood, but hypothalamic involvement was suspected as the hypothalamus represents the cerebral management center of sleep regulation and pain control.
Fourteen patients with HH and 14 age-matched and gender-matched healthy controls were investigated using magnetic resonance imaging–based voxel-based morphometry.
We detected gray matter volume decrease in the posterior hypothalamus of HH patients. Additional gray matter decrease was observed in brain areas known to be associated with cerebral pain processing, including the cingulate cortex, operculum, and frontal lobe, as well as in the temporal lobe.
Our data confirm the hypothesized involvement of the posterior hypothalamus in the pathophysiology of HH and emphasize the importance of this structure for sleep regulation and pain control. ANN NEUROL 2010