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Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria

  1. Chris H. Polman MD, PhD1,*,
  2. Stephen C. Reingold PhD2,
  3. Brenda Banwell MD3,
  4. Michel Clanet MD4,
  5. Jeffrey A. Cohen MD5,
  6. Massimo Filippi MD6,
  7. Kazuo Fujihara MD7,
  8. Eva Havrdova MD, PhD8,
  9. Michael Hutchinson MD9,
  10. Ludwig Kappos MD10,
  11. Fred D. Lublin MD11,
  12. Xavier Montalban MD12,
  13. Paul O'Connor MD13,
  14. Magnhild Sandberg-Wollheim MD, PhD14,
  15. Alan J. Thompson MD15,
  16. Emmanuelle Waubant MD, PhD16,
  17. Brian Weinshenker MD17,
  18. Jerry S. Wolinsky MD18

Article first published online: 8 MAR 2011

DOI: 10.1002/ana.22366

Issue

Annals of Neurology

Annals of Neurology

Volume 69, Issue 2, pages 292–302, February 2011

Additional Information

How to Cite

Polman, C. H., Reingold, S. C., Banwell, B., Clanet, M., Cohen, J. A., Filippi, M., Fujihara, K., Havrdova, E., Hutchinson, M., Kappos, L., Lublin, F. D., Montalban, X., O'Connor, P., Sandberg-Wollheim, M., Thompson, A. J., Waubant, E., Weinshenker, B. and Wolinsky, J. S. (2011), Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria. Ann Neurol., 69: 292–302. doi: 10.1002/ana.22366

Author Information

  1. 1

    Department of Neurology, Free University, Amsterdam, the Netherlands

  2. 2

    Scientific and Clinical Review Associates LLC, New York, NY

  3. 3

    Division of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada

  4. 4

    Department of Neurosciences, University Hospital Center, Toulouse, France

  5. 5

    Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinical Foundation, Cleveland, OH

  6. 6

    Neuroimaging Research Unit, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy

  7. 7

    Department of Multiple Sclerosis Therapeutics, Tohoku University Graduate School of Medicine, Sendai, Japan

  8. 8

    Department of Neurology, First Faculty of Medicine, Charles University, Prague, Czech Republic

  9. 9

    St Vincent's University Hospital, Elm Park, Dublin, Ireland

  10. 10

    Departments of Neurology and Biomedicine, University Hospital, Kantonsspital, Basel, Switzerland

  11. 11

    Corrine Goldsmith Dickinson Center for Multiple Sclerosis, Department of Neurology, Mount Sinai School of Medicine, New York, NY

  12. 12

    Clinical Neuroimmunology Unit, Multiple Sclerosis Center of Catalonia, University Hospital Vall d'Hebron, Barcelona, Spain

  13. 13

    Division of Neurology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada

  14. 14

    Department of Neurology, University Hospital, Lund, Sweden

  15. 15

    University College London Institute of Neurology, United Kingdom

  16. 16

    Multiple Sclerosis Center, University of California, San Francisco, CA

  17. 17

    Department of Neurology, Mayo Clinic, Rochester, MN

  18. 18

    Department of Neurology, University of Texas Health Sciences Center, Houston, TX

*Department of Neurology, VU Medical Center Amsterdam, PO Box 7057, 1007 MB Amsterdam, the Netherlands

Publication History

  1. Issue published online: 8 MAR 2011
  2. Article first published online: 8 MAR 2011
  3. Accepted manuscript online: 11 JAN 2011 09:11AM EST
  4. Manuscript Accepted: 29 DEC 2010
  5. Manuscript Revised: 23 DEC 2010
  6. Manuscript Received: 2 NOV 2010

Funded by

  • Unknown funding agency

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Abstract

New evidence and consensus has led to further revision of the McDonald Criteria for diagnosis of multiple sclerosis. The use of imaging for demonstration of dissemination of central nervous system lesions in space and time has been simplified, and in some circumstances dissemination in space and time can be established by a single scan. These revisions simplify the Criteria, preserve their diagnostic sensitivity and specificity, address their applicability across populations, and may allow earlier diagnosis and more uniform and widespread use. Ann Neurol 2011

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