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Analysis of cerebrospinal fluid from chronic fatigue syndrome patients for multiple human ubiquitous viruses and xenotropic murine leukemia-related virus
Article first published online: 6 APR 2011
DOI: 10.1002/ana.22389
Copyright © 2011 American Neurological Association
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How to Cite
Schutzer, S. E., Rounds, M. A., Natelson, B. H., Ecker, D. J. and Eshoo, M. W. (2011), Analysis of cerebrospinal fluid from chronic fatigue syndrome patients for multiple human ubiquitous viruses and xenotropic murine leukemia-related virus. Ann Neurol., 69: 735–738. doi: 10.1002/ana.22389
Publication History
- Issue published online: 22 APR 2011
- Article first published online: 6 APR 2011
- Accepted manuscript online: 4 FEB 2011 08:50AM EST
- Manuscript Accepted: 24 JAN 2011
- Manuscript Revised: 20 JAN 2011
- Manuscript Received: 22 DEC 2010
- Abstract
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- Cited By
Abstract
Recent reports showed many patients with chronic fatigue syndrome (CFS) harbor a retrovirus, xenotropic murine leukemia-related virus (XMRV), in blood; other studies could not replicate this finding. A useful next step would be to examine cerebrospinal fluid, because in some patients CFS is thought to be a brain disorder. Finding a microbe in the central nervous system would have greater significance than in blood because of the integrity of the blood–brain barrier. We examined cerebrospinal fluid from 43 CFS patients using polymerase chain reaction techniques, but did not find XMRV or multiple other common viruses, suggesting that exploration of other causes or pathogenetic mechanisms is warranted. Ann Neurol 2011;