Amyloid-beta plaque growth in cognitively normal adults: Longitudinal [11C]Pittsburgh compound B data

Authors

  • Andrei G. Vlassenko MD, PhD,

    1. Department of Radiology, Washington University School of Medicine, St Louis, MO
    2. Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO
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  • Mark A. Mintun MD,

    1. Department of Radiology, Washington University School of Medicine, St Louis, MO
    2. Avid Radiopharmaceuticals, Philadelphia, PA
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  • Chengjie Xiong PhD,

    1. Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO
    2. Division of Biostatistics, Washington University School of Medicine, St Louis, MO
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  • Yvette I. Sheline MD,

    1. Department of Radiology, Washington University School of Medicine, St Louis, MO
    2. Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO
    3. Department of Psychiatry, Washington University School of Medicine, St Louis, MO
    4. Department of Neurology, Washington University School of Medicine, St Louis, MO
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  • Alison M. Goate DPhil,

    1. Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO
    2. Department of Psychiatry, Washington University School of Medicine, St Louis, MO
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  • Tammie L. S. Benzinger MD, PhD,

    1. Department of Radiology, Washington University School of Medicine, St Louis, MO
    2. Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO
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  • John C. Morris MD

    Corresponding author
    1. Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO
    2. Department of Neurology, Washington University School of Medicine, St Louis, MO
    • Friedman Distinguished Professor of Neurology, Director, Knight Alzheimer Disease Research Center, Director, Harvey A. Friedman Center for Aging, Washington University School of Medicine, 4488 Forest Park Avenue, Suite 130, St Louis, MO 63108
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Abstract

Amyloid-beta (Aβ) accumulation was evaluated with 2 [11C]Pittsburgh compound B (PiB) positron emission tomography scans about 2.5 years apart in 146 cognitively normal adults. Seventeen of 21 participants with initially elevated Aβ deposition demonstrated subsequent Aβ plaque growth (approximately 8.0% per year), and none reverted to a state of no Aβ deposits. Ten individuals converted from negative to positive PiB status, based on a threshold of the mean cortical binding potential, representing a conversion rate of 3.1% per year. Individuals with an ε4 allele of apolipoprotein E demonstrated increased incidence of conversion (7.0% per year). Our findings suggest that the major growth in Aβ burden occurs during a preclinical stage of Alzheimer disease (AD), prior to the onset of AD-related symptoms. Ann Neurol 2011

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