Middle cerebral artery intraplaque hemorrhage: Prevalence and Clinical Relevance
Version of Record online: 24 FEB 2012
Copyright © 2012 American Neurological Association
Annals of Neurology
Volume 71, Issue 2, pages 195–198, February 2012
How to Cite
Xu, W.-H., Li, M.-L., Gao, S., Ni, J., Yao, M., Zhou, L.-X., Peng, B., Feng, F., Jin, Z.-Y. and Cui, L.-Y. (2012), Middle cerebral artery intraplaque hemorrhage: Prevalence and Clinical Relevance. Ann Neurol., 71: 195–198. doi: 10.1002/ana.22626
- Issue online: 24 FEB 2012
- Version of Record online: 24 FEB 2012
- Accepted manuscript online: 12 SEP 2011 08:28AM EST
- Manuscript Accepted: 2 SEP 2011
- Manuscript Revised: 14 AUG 2011
- Manuscript Received: 28 JUN 2011
Little is known about the composition of middle cerebral artery (MCA) plaques and how they relate to clinical status. Using high-resolution magnetic resonance imaging (HR-MRI), we aimed to examine the occurrence of high signal on T1-weighted fat-suppressed images (HST1) of MCA plaques, which are highly suggestive of fresh or recent intraplaque hemorrhage.
We retrospectively analyzed the HR-MRI and clinical data of 107 adult patients with high-grade (>70%) MCA stenosis. On HR-MRI, HST1 within an MCA plaque was defined as an area with an intensity >150% of the signal of adjacent muscles. The relationship between HST1 and clinical presentations was analyzed.
A total of 109 stenotic MCAs (46 symptomatic and 63 asymptomatic) on 981 image slices were analyzed. HST1 was revealed on HR-MRI in 11 vessels (10.1%, 9 symptomatic and 2 asymptomatic). The occurrence rate of HST1 between symptomatic and asymptomatic MCAs was significantly different (19.6% vs 3.2%, p = 0.01).
HST1 within MCA plaque on HR-MRI is associated with ipsilateral stroke. Our results provide new insight into the vascular biology of MCA atherosclerosis. Ann Neurol 2012;71:195–198