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Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis

Authors

  • Ajit Singh Dhaunchak PhD,

    1. Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University and McGill University Health Centre, Montreal, Quebec, Canada
    2. Program in NeuroEngineering of McGill University, Montreal, Quebec, Canada
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  • Christopher Becker PhD,

    1. PPD Biomarker Discovery, Inc and Caprion Proteomics, Menlo Park, CA
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  • Howard Schulman PhD,

    1. PPD Biomarker Discovery, Inc and Caprion Proteomics, Menlo Park, CA
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  • Omar De Faria Jr MSc,

    1. Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University and McGill University Health Centre, Montreal, Quebec, Canada
    2. Program in NeuroEngineering of McGill University, Montreal, Quebec, Canada
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  • Sathyanath Rajasekharan PhD,

    1. Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University and McGill University Health Centre, Montreal, Quebec, Canada
    2. Experimental Therapeutics Program, Montreal Neurological Institute and Hospital, McGill University and McGill University Health Centre, Montreal, Quebec, Canada
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  • Brenda Banwell MD,

    1. Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada
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  • David R. Colman PhD,

    1. Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University and McGill University Health Centre, Montreal, Quebec, Canada
    2. Program in NeuroEngineering of McGill University, Montreal, Quebec, Canada
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  • Amit Bar-Or MD,

    Corresponding author
    1. Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University and McGill University Health Centre, Montreal, Quebec, Canada
    2. Experimental Therapeutics Program, Montreal Neurological Institute and Hospital, McGill University and McGill University Health Centre, Montreal, Quebec, Canada
    • Neuroimmunology Unit and Experimental Therapeutics Program, Montreal Neurological Institute and Hospital, McGill University and the McGill University Health Centre, 3801 University Street, Room 111, Montreal, Quebec, H3A2B4, Canada
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  • on behalf of the Canadian Pediatric Demyelinating Disease Group


  • Members of the Canadian Pediatric Demyelinating Disease Network are listed in the Appendixat the end of this article.

Abstract

Cerebrospinal fluid samples collected from children during initial presentation of central nervous system inflammation, who may or may not subsequently be diagnosed as having multiple sclerosis (MS), were subjected to large-scale proteomics screening. Unexpectedly, major compact myelin membrane proteins typically implicated in MS were not detected. However, multiple molecules that localize to the node of Ranvier and the surrounding axoglial apparatus membrane were implicated, indicating perturbed axon–glial interactions in those children destined for diagnosis of MS. Ann Neurol 2012;

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