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Original Article

Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory

  1. Yiying Zhang MD, MS1,
  2. Zhipeng Xu MD, PhD1,
  3. Hui Wang MD1,2,
  4. Yuanlin Dong MD, MS1,
  5. Hai Ning Shi PhD, DVM3,
  6. Deborah J. Culley MD4,
  7. Gregory Crosby MD4,
  8. Edward R. Marcantonio MD5,
  9. Rudolph E. Tanzi PhD.6,
  10. Zhongcong Xie MD, PhD1,*

Article first published online: 24 FEB 2012

DOI: 10.1002/ana.23536

Issue

Annals of Neurology

Annals of Neurology

Volume 71, Issue 5, pages 687–698, May 2012

Additional Information

How to Cite

Zhang, Y., Xu, Z., Wang, H., Dong, Y., Shi, H. N., Culley, D. J., Crosby, G., Marcantonio, E. R., Tanzi, R. E. and Xie, Z. (2012), Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Ann Neurol., 71: 687–698. doi: 10.1002/ana.23536

Author Information

  1. 1

    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA

  2. 2

    Department of Anesthesia, Beijing Chaoyang Hospital, Capital Medical University, Beijing, P.R. China

  3. 3

    Mucosal Immunology Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA

  4. 4

    Department of Anesthesia, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

  5. 5

    Divisions of General Medicine and Primary Care and Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA

  6. 6

    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA

*Associate Professor of Anesthesia, Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 149 13th St., Room 4310, Charlestown, MA 02129-2060

Publication History

  1. Issue published online: 20 APR 2012
  2. Article first published online: 24 FEB 2012
  3. Accepted manuscript online: 19 JAN 2012 06:50AM EST
  4. Manuscript Accepted: 6 JAN 2012
  5. Manuscript Revised: 28 NOV 2011
  6. Manuscript Received: 8 AUG 2011

Funded by

  • NIH grants. Grant Numbers: K08 NS048140, (NINDS), R21 AG029856 (NIA), R01 GM088801 (NINDS) (Z. Xie)
  • American Geriatrics Society Jahnigen Award (Z. Xie)
  • Alzheimer's Association (Z. Xie)
  • Cure Alzheimer's Fund (Z. Xie)
  • NIH. Grant Number: DK082427 (NIDDK) (H.S.)

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View Full Article with Supporting Information (HTML) Get PDF (1327K)