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ANA_23593_sm_SuppFig1.pdf27KSupplemental Figure 1. Determination of population for analysis. *Eligible as of January 1, 1998. Most ineligibility (98.5%) was due to the age restriction; only 1.5% of deaths or losses to follow-up had occurred by the start of the cognitive sub-study. †Participation rates among those with dietary data are identical to rates for the entire cognitive sub-study as reported in Kang JH et al. BMJ. 2007;334(7601):987. N=594 completed waves 1 and 2 but not wave 3; n=146 completed waves 1 and 3 but not wave 2.
ANA_23593_sm_SuppFig2.pdf46KSupplemental Figure 2. Least-squares Means Test Scores over 4 years, by Quintiles of Saturated and Mono-unsaturated Fat Intakes: Multivariable-adjusted with Initial Cognitive Score-x-Follow-up Time Interaction*. *SFA = saturated fatty acid; MUFA = mono-unsaturated fatty acid; PUFA = poly-unsaturated fatty acid; Trans = trans fatty acid; Q1 = lowest quintile of intake; Q5 = highest quintile of intake; models adjusted for mean-centered age at initial cognitive assessment (continuous, in years), educational attainment (bachelor's degree or above versus associate's degree), race (white/non-white), annual household income (≥$50,000/less), randomized treatment assignment (aspirin, vitamin E), other fat intake, protein intake, total energy intake, all covariate-by-time interactions, and interaction terms for initial cognitive score-x-follow-up time indicators. P-values are from the Wald tests of interactions between fat type consumption level (medians-per-quintile) and time. † Global score combines results of the TICS (Telephone Interview for Cognitive Status), category fluency, immediate and delayed recall trials of East Boston Memory Test (EBMT), and delayed recall trial of the TICS 10-word list; verbal memory score combines results of the immediate and delayed recall trials of EBMT and the TICS 10-word list. The mean (SD) span between the 1st and 3rd assessments was 4.0 (0.3) years. Adjusted least-squares means were obtained from the repeated measures analysis models involving N=6,172 participants for the global score and N=6,176 participants for verbal memory.
ANA_23593_sm_SuppTab1.doc52KSupplemental Table. Multivariable-adjusted* Odds Ratios (95% Confidence Intervals) of Worst Cognitive Change over 4 years, by Percent of Total Energy Substitutions†.

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