Coordinated reset has sustained aftereffects in Parkinsonian monkeys

Authors

  • Peter A. Tass MD, PhD,

    1. Institute for Medicine and Neurosciences, Research Center Jülich, Jülich, Germany
    2. Division for Neuromodulation, Medical School, University of Cologne, Cologne, Germany
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  • Li Qin PhD,

    1. Institute of Laboratory Animal Sciences, China Academy of Medical Sciences, Beijing, China
    2. Motac Neuroscience, Manchester, United Kingdom
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  • Christian Hauptmann PhD,

    1. Institute for Medicine and Neurosciences, Research Center Jülich, Jülich, Germany
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  • Sandra Dovero BSc,

    1. Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France
    2. CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France
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  • Erwan Bezard PhD,

    1. Institute of Laboratory Animal Sciences, China Academy of Medical Sciences, Beijing, China
    2. Motac Neuroscience, Manchester, United Kingdom
    3. Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France
    4. CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France
    5. Service de Neurologie, CHU de Bordeaux, Pessac, France
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  • Thomas Boraud MD, PhD,

    1. Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France
    2. CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France
    3. Service de Neurologie, CHU de Bordeaux, Pessac, France
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  • Wassilios G. Meissner MD, PhD

    Corresponding author
    1. Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France
    2. CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France
    3. Service de Neurologie, CHU de Bordeaux, Pessac, France
    4. Centre de référence atrophie multisystématisée, CHU de Bordeaux, Pessac, France
    • Service de Neurologie, Hôpital du Haut-Lévêque, CHU de Bordeaux, Avenue Magellan, 33604 Pessac cedex, France
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Abstract

Coordinated reset neuromodulation consists of the application of consecutive brief high-frequency pulse trains through the different contacts of the stimulation electrode. In theoretical studies, by achieving unlearning of abnormal connectivity between neurons, coordinated reset neuromodulation reduces pathological synchronization, a hallmark feature of Parkinson's disease pathophysiology. Here we show that coordinated reset neuromodulation of the subthalamic nucleus has both acute and sustained long-lasting aftereffects on motor function in parkinsonian nonhuman primates. Long-lasting aftereffects were not observed with classical deep brain stimulation. These observations encourage further development of coordinated reset neuromodulation for treating motor symptoms in Parkinson disease patients. ANN NEUROL 2012;72:816–820

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