Risk for myasthenia gravis maps to a 151ProAla change in TNIP1 and to human leukocyte antigen-B*08
Article first published online: 10 OCT 2012
Copyright © 2012 American Neurological Association
Annals of Neurology
Volume 72, Issue 6, pages 927–935, December 2012
How to Cite
Gregersen, P. K., Kosoy, R., Lee, A. T., Lamb, J., Sussman, J., McKee, D., Simpfendorfer, K. R., Pirskanen-Matell, R., Piehl, F., Pan-Hammarstrom, Q., Verschuuren, J. J. G. M., Titulaer, M. J., Niks, E. H., Marx, A., Ströbel, P., Tackenberg, B., Pütz, M., Maniaol, A., Elsais, A., Tallaksen, C., Harbo, H. F., Lie, B. A., Raychaudhuri, S., de Bakker, P. I. W., Melms, A., Garchon, H.-J., Willcox, N., Hammarstrom, L. and Seldin, M. F. (2012), Risk for myasthenia gravis maps to a 151ProAla change in TNIP1 and to human leukocyte antigen-B*08. Ann Neurol., 72: 927–935. doi: 10.1002/ana.23691
- Issue published online: 31 DEC 2012
- Article first published online: 10 OCT 2012
- Accepted manuscript online: 16 JUL 2012 05:12PM EST
- Manuscript Accepted: 13 JUN 2012
- Manuscript Revised: 18 MAY 2012
- Manuscript Received: 22 FEB 2012
The objective of this study is to comprehensively define the genetic basis of early onset myasthenia gravis (EOMG).
We have carried out a 2-stage genome-wide association study on a total of 649 North European EOMG patients. Cases were matched 1:4 with controls of European ancestry. We performed imputation and conditional analyses across the major histocompatibility complex, as well as in the top regions of association outside the human leukocyte antigen (HLA) region.
We observed the strongest association in the HLA class I region at rs7750641 (p = 1.2 × 10−92; odds ratio [OR], 6.25). By imputation and conditional analyses, HLA-B*08 proves to be the major associated allele (p = 2.87 × 10−113; OR, 6.41). In addition to the expected association with PTPN22 (rs2476601; OR, 1.71; p = 8.2 × 10−10), an imputed coding variant (rs2233290) at position 151 (ProAla) in the TNFAIP3-interacting protein 1, TNIP1, confers even stronger risk than PTPN22 (OR, 1.91; p = 3.2 × 10−10).
The association at TNIP1 in EOMG implies disease mechanisms involving ubiquitin-dependent dysregulation of NF-κB signaling. The localization of the major HLA signal to the HLA-B*08 allele suggests that CD8+ T cells may play a key role in disease initiation or pathogenesis. ANN NEUROL 2012;