Additional supporting information can be found in the online version of this article.

ANA_23738_sm_SuppFig1.tif1735KSupporting Information Figure 1. Risk of hemorrhagic stroke as a function of plasma 25-hydroxyvitamin D by seasonally adjusted percentile categories(top) and by clinical categories of absolute plasma 25-hydroxyvitamin D concentration in nmol/L(bottom). Multivariable adjustment was for age, gender, body mass index, physical activity level, smoking, alcohol consumption, total cholesterol level, high-density lipoprotein cholesterol level, hypertension, diabetes mellitus, atrial fibrillation, hormone replacement therapy, lipid lowering therapy, use of antihypertensive medication, and estimated glomerular filtration rate; for analysis of clinical categories month of blood sampling was also adjusted for. Black dots represent hazard ratio, and error bars the 95% confidence interval. P-values for trend are by Cuzick's extension of a Wilcoxon rank-sum test.
ANA_23738_sm_SuppFig2.tif61KSupporting Information Figure 2. Funnel plot with 95% confidence limits for meta-analysis of 10 prospective studies of plasma 25-hydroxyvitamin D levels and risk of ischemic stroke/stroke. The horizontal line indicates the summary effect estimate of the meta-analysis and the oblique lines the pseudo 95% confidence limits. Each study is represented by an open circle. Z- and p-values for Begg's rank correlation test are continuity corrected.
ANA_23738_sm_SuppInfo.rtf48KSupporting Information

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