Additional Supporting Information may be found in the online version of this article.

ANA_23749_sm_SuppFig1.tif579KSupporting Information Figure 1. Frequency distribution Frequency distribution of the IgG index in the discovery series. Distribution of the IgG index is shown for the original data as well as the ln transformed data.
ANA_23749_sm_SuppFig2.tif1100KSupporting Information Figure 2. IgG levels and the rs10136766 genotype Intrathecal IgG levels, determined as IgG index, are shown for patients being homozygous for the effect allele of SNP rs10136766 (AA), being heterozygous for this SNP (AG) or being homozygous with GG. The discovery series, the first and the second replication series are displayed. The median is shown for each group as a horizontal lane, the minimum and maximum are shown as vertical lines. Both the original IgG index values and the natural logarithm of the IgG index are shown in this graph to illustrate results; for linear regression analysis the natural logarithm of the IgG index was used.
ANA_23749_sm_SuppFig3.tif111KSupporting Information Figure 3. IgG index over time In 11 patients with MS the IgG index was determined in two different CSF analyses with a time interval of 2-28 months (mean 12 months).
ANA_23749_sm_SuppTables.doc152KSupporting Information Tables.

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