Nitric oxide signaling in the brain: A new target for inhaled nitric oxide?

Authors

  • Christiane Charriaut-Marlangue PhD,

    1. Paris Diderot University, Sorbonne Paris Cité, INSERM U676, Paris, France
    2. PremUP Foundation
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  • Philippe Bonnin PhD, MD,

    1. Paris Diderot University, Sorbonne Paris Cité, Public Hospital Network of Paris, Lariboisière Hospital, Clinical Physiology–Functional Explorations
    2. Paris Diderot University, Sorbonne Paris Cité, National Institute of Health and Medical Research, Paris, France
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  • Hoa Pham PhD,

    1. Paris Diderot University, Sorbonne Paris Cité, INSERM U676, Paris, France
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  • Gauthier Loron MD,

    1. Paris Diderot University, Sorbonne Paris Cité, INSERM U676, Paris, France
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  • Pierre-Louis Leger MD,

    1. Paris Diderot University, Sorbonne Paris Cité, INSERM U676, Paris, France
    2. PremUP Foundation
    3. Pierre and Marie Curie University–Paris VI, Public Hospital Network of Paris, Armand Trousseau Hospital, Pediatric Resuscitation Service
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  • Pierre Gressens PhD, MD,

    1. Paris Diderot University, Sorbonne Paris Cité, INSERM U676, Paris, France
    2. PremUP Foundation
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  • Sylvain Renolleau PhD, MD,

    1. PremUP Foundation
    2. Pierre and Marie Curie University–Paris VI, Public Hospital Network of Paris, Armand Trousseau Hospital, Pediatric Resuscitation Service
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  • Olivier Baud PhD, MD

    Corresponding author
    1. PremUP Foundation
    2. Paris Diderot University, Sorbonne Paris Cité, Public Hospital Network of Paris, Neonatal Resuscitation Service, Robert Debré Hospital
    • Paris Diderot University, Sorbonne Paris Cité, INSERM U676, Paris, France
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Address correspondence to Dr Baud, INSERM UMR 676 and NICU, Hôpital Robert Debré, 48 Bd Sérurier, F-75019 Paris, France. E-mail: olivier.baud@rdb.aphp.fr

Abstract

Nitric oxide (NO) is a powerful vasodilator, involved in both physiological functions and pathophysiological alterations of various regulatory processes, for example, the maintenance of vascular tone and inflammation. The recently demonstrated impact of exogenous NO on the central nervous system extends its role under normal and pathological conditions. At times neuroprotective, at times neurotoxic, NO is capable of different effects depending upon the extent of cerebral damage, the cellular redox state, and the spatiotemporal coordinates and concentration at which it is synthesized. This review provides new insights into the short- and long-term effects of endogenous and exogenous NO in brain injury. ANN NEUROL 2013;73:442–448

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