Intrinsic connectivity network disruption in progressive supranuclear palsy
Article first published online: 27 MAR 2013
Copyright © 2012 American Neurological Association
Annals of Neurology
Volume 73, Issue 5, pages 603–616, May 2013
How to Cite
Gardner, R. C., Boxer, A. L., Trujillo, A., Mirsky, J. B., Guo, C. C., Gennatas, E. D., Heuer, H. W., Fine, E., Zhou, J., Kramer, J. H., Miller, B. L. and Seeley, W. W. (2013), Intrinsic connectivity network disruption in progressive supranuclear palsy. Ann Neurol., 73: 603–616. doi: 10.1002/ana.23844
- Issue published online: 28 MAY 2013
- Article first published online: 27 MAR 2013
- Accepted manuscript online: 29 JAN 2013 04:52AM EST
- Manuscript Accepted: 21 DEC 2012
- Manuscript Revised: 17 DEC 2012
- Manuscript Received: 24 JAN 2012
Progressive supranuclear palsy (PSP) has been conceptualized as a large-scale network disruption, but the specific network targeted has not been fully characterized. We sought to delineate the affected network in patients with clinical PSP.
Using task-free functional magnetic resonance imaging, we mapped intrinsic connectivity to the dorsal midbrain tegmentum (dMT), a region that shows focal atrophy in PSP. Two healthy control groups (1 young, 1 older) were used to define and replicate the normal connectivity pattern, and patients with PSP were compared to an independent matched healthy control group on measures of network connectivity.
Healthy young and older subjects showed a convergent pattern of connectivity to the dMT, including brainstem, cerebellar, diencephalic, basal ganglia, and cortical regions involved in skeletomotor, oculomotor, and executive control. Patients with PSP showed significant connectivity disruptions within this network, particularly within corticosubcortical and cortico-brainstem interactions. Patients with more severe functional impairment showed lower mean dMT network connectivity scores.
This study defines a PSP-related intrinsic connectivity network in the healthy brain and demonstrates the sensitivity of network-based imaging methods to PSP-related physiological and clinical changes. Ann Neurol 2013;73:603–616