Additional supporting information can be found in the online version of this article.


Supplementary Figure 1. Time-lines of the in vivo and in vitro rodent experiments.

Supplementary Figure 2. Absence of sensitizing effect following activation of AMPA/kainate receptors.

Supplementary Figure 3. Percentage of non-responsive neurons to calcium mobilization after ibotenate exposure in IL-1β and PBS groups.

Supplementary Figure 4. GRK2 immunostaining in IL-1β and PBS-treated mouse primary neurons.

Supplementary Figure 5. Effect of astrocyte deletion of GRK2.

Supplementary Table 1. Sample size and number of replicates for each experiment

Supplementary Table 2. Sequences of oligonucleotide primers used for qRT-PCR

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