G protein–coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration
Article first published online: 14 MAR 2013
Copyright © 2013 American Neurological Association
Annals of Neurology
Volume 73, Issue 5, pages 667–678, May 2013
How to Cite
Degos, V., Peineau, S., Nijboer, C., Kaindl, A. M., Sigaut, S., Favrais, G., Plaisant, F., Teissier, N., Gouadon, E., Lombet, A., Saliba, E., Collingridge, G. L., Maze, M., Nicoletti, F., Heijnen, C., Mantz, J., Kavelaars, A. and Gressens, P. (2013), G protein–coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration. Ann Neurol., 73: 667–678. doi: 10.1002/ana.23868
- Issue published online: 28 MAY 2013
- Article first published online: 14 MAR 2013
- Accepted manuscript online: 11 FEB 2013 04:44AM EST
- Manuscript Accepted: 5 FEB 2013
- Manuscript Revised: 3 JAN 2013
- Manuscript Received: 13 JUL 2012
Additional supporting information can be found in the online version of this article.
Supplementary Figure 1. Time-lines of the in vivo and in vitro rodent experiments.
Supplementary Figure 2. Absence of sensitizing effect following activation of AMPA/kainate receptors.
Supplementary Figure 3. Percentage of non-responsive neurons to calcium mobilization after ibotenate exposure in IL-1β and PBS groups.
Supplementary Figure 4. GRK2 immunostaining in IL-1β and PBS-treated mouse primary neurons.
Supplementary Figure 5. Effect of astrocyte deletion of GRK2.
Supplementary Table 1. Sample size and number of replicates for each experiment
Supplementary Table 2. Sequences of oligonucleotide primers used for qRT-PCR
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