Brain–machine interface in chronic stroke rehabilitation: A controlled study
Article first published online: 7 AUG 2013
Copyright © 2013 American Neurological Association
Annals of Neurology
Volume 74, Issue 1, pages 100–108, July 2013
How to Cite
Ramos-Murguialday, A., Broetz, D., Rea, M., Läer, L., Yilmaz, Ö., Brasil, F. L., Liberati, G., Curado, M. R., Garcia-Cossio, E., Vyziotis, A., Cho, W., Agostini, M., Soares, E., Soekadar, S., Caria, A., Cohen, L. G. and Birbaumer, N. (2013), Brain–machine interface in chronic stroke rehabilitation: A controlled study. Ann Neurol., 74: 100–108. doi: 10.1002/ana.23879
- Issue published online: 27 AUG 2013
- Article first published online: 7 AUG 2013
- Accepted manuscript online: 12 MAR 2013 10:07AM EST
- Manuscript Accepted: 1 MAR 2013
- Manuscript Revised: 12 FEB 2013
- Manuscript Received: 4 NOV 2012
Chronic stroke patients with severe hand weakness respond poorly to rehabilitation efforts. Here, we evaluated efficacy of daily brain–machine interface (BMI) training to increase the hypothesized beneficial effects of physiotherapy alone in patients with severe paresis in a double-blind sham-controlled design proof of concept study.
Thirty-two chronic stroke patients with severe hand weakness were randomly assigned to 2 matched groups and participated in 17.8 ± 1.4 days of training rewarding desynchronization of ipsilesional oscillatory sensorimotor rhythms with contingent online movements of hand and arm orthoses (experimental group, n = 16). In the control group (sham group, n = 16), movements of the orthoses occurred randomly. Both groups received identical behavioral physiotherapy immediately following BMI training or the control intervention. Upper limb motor function scores, electromyography from arm and hand muscles, placebo–expectancy effects, and functional magnetic resonance imaging (fMRI) blood oxygenation level–dependent activity were assessed before and after intervention.
A significant group × time interaction in upper limb (combined hand and modified arm) Fugl–Meyer assessment (cFMA) motor scores was found. cFMA scores improved more in the experimental than in the control group, presenting a significant improvement of cFMA scores (3.41 ± 0.563-point difference, p = 0.018) reflecting a clinically meaningful change from no activity to some in paretic muscles. cFMA improvements in the experimental group correlated with changes in fMRI laterality index and with paretic hand electromyography activity. Placebo–expectancy scores were comparable for both groups.
The addition of BMI training to behaviorally oriented physiotherapy can be used to induce functional improvements in motor function in chronic stroke patients without residual finger movements and may open a new door in stroke neurorehabilitation. ANN NEUROL 2013;74:100–108