Additional supporting information can be found in the online version of this article.

ana23922-sup-0001-suppinfo01.pdf18KSupplemental Figure 1: Diagram showing RVM injections. Onsite injections (N=89 from all experiments, not shown for clarity) were considered as those inside the square. Offsite injections (N-22) are represented as O.
ana23922-sup-0002-suppinfo02.docx11KSupplemental Figure 2: Sumatriptan (0.3 or 1.2 mg/kg, i.v.) does not produce CPP in rats with dural IM. A) Protocol for injections on conditioning day. B) No significant differences were observed in rats treated with dural IM or SIF that received sumatriptan (0.3 or 1.2 mg/kg, i.v.) 3 hrs post dural injection (N=9-10 per group). C) Systemic sumatriptan (0.6 mg/kg, s.c., administered 30 min, 1, 2 or 3h post dura injection) does not induced release of DA in the NAc of IM treated rats. No difference in DA release after cocaine was found in rats that received systemic sumatriptan.

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