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Therapeutic prospects for migraine: Can paradise be regained?


  • Peter J. Goadsby MD, PhD, DSc, FRACP, FRCP

    Corresponding author
    1. Headache Group, Department of Neurology, University of California, San Francisco, San Francisco, CA
    • Address correspondence to Dr Goadsby, UCSF Headache Center, 1701 Divisadero St, San Francisco CA 94115. E-mail:

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Migraine is a common, complex brain disorder whose biology is becoming better understood. Despite being the most disabling of the neurological disorders on a worldwide basis, headache disorders broadly, and migraine in particular, have poor research funding and a limited academic base. Given a modicum of investment, new targets, such as calcitonin gene-related peptide–based mechanisms, and entirely novel neuromodulation approaches illustrate that much can be done to improve patient care. Genetics and neuroimaging combined with excellent clinical phenotyping and translational neuroscience approaches are set to transform life for a cohort of patients with these common brain disorders. Ann Neurol 2013;74:423–434