Perinatal risk factors in children with serious motor and mental handicaps
Article first published online: 7 OCT 2004
Copyright © 1977 American Neurological Association
Annals of Neurology
Volume 2, Issue 5, pages 371–377, November 1977
How to Cite
Nelson, K. B. and Broman, S. H. (1977), Perinatal risk factors in children with serious motor and mental handicaps. Ann Neurol., 2: 371–377. doi: 10.1002/ana.410020505
- Issue published online: 7 OCT 2004
- Article first published online: 7 OCT 2004
- Manuscript Accepted: 9 MAY 1977
Fifty children with marked neurological abnormality manifested by moderate or severe motor disability and severe mental retardation were compared with a large control population with respect to prospectively ascertained perinatal characteristics. None of 60 prenatal factors distinguished the affected group from controls. In labor and delivery, lowest fetal heart rate in the second stage of labor, arrested progress of labor, and use of midforceps discriminated between the two groups. Neonatal characteristics of children who were later severely handicapped differed from controls, particularly with respect to difficulty in initiating and maintaining respiration, intracranial hemorrhage, neonatal seizures, low birth weight and small head circumference, lowest hemoglobin or hematocrit, and overall neurological status.
Multivariate analysis, including factors from all epochs, indicated that intracranial hemorrhage and neonatal seizures were the strongest independent discriminators between the neurologically impaired children and controls.