Identification of speech lateralization by intracarotid injection of methohexital

Authors

  • L. James Willmore,

    MD
    1. Neurology Service, Veterans Administration Hospital, and the Departments of Neurology, Neurosurgery, and Neuroscience, University of Florida College of Medicine, Gainesville, FL
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  • Dr. B. Joe Wilder,

    MD, Corresponding author
    1. Neurology Service, Veterans Administration Hospital, and the Departments of Neurology, Neurosurgery, and Neuroscience, University of Florida College of Medicine, Gainesville, FL
    • Neurology Service (127), Veterans Administration Hosptial, Gainesville, FL 32602
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  • Assa Mayersdorf,

    MD
    1. Neurology Service, Veterans Administration Hospital, and the Departments of Neurology, Neurosurgery, and Neuroscience, University of Florida College of Medicine, Gainesville, FL
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  • R. Eugene Ramsay,

    MD
    1. Neurology Service, Veterans Administration Hospital, and the Departments of Neurology, Neurosurgery, and Neuroscience, University of Florida College of Medicine, Gainesville, FL
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  • George W. Sypert

    MD
    1. Neurology Service, Veterans Administration Hospital, and the Departments of Neurology, Neurosurgery, and Neuroscience, University of Florida College of Medicine, Gainesville, FL
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Abstract

Speech lateralization was assessed in 25 patients with epilepsy by direct carotid injection or carotid catheterization from a femoral approach. Hemispheric anesthesia was induced by intracarotid injection of the rapidly acting barbiturate methohexital. This technique allowed same-day study of both hemispheres, permitted repeated injection of either carotid artery without accumulation of methohexital sufficient to cause systemic effects, and added little to the total time required for three-vessel cerebral angiography. Unilateral seizures were induced by methohexital injection in 4 patients. No other complication secondary to the methohexital study was observed.

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