Sparing of the onufrowicz nucleus in sacral anterior horn lesions

Authors

  • Dr. Makoto Iwata,

    MD, Corresponding author
    1. Division of Neuropathology, Department of Pathology, Montefiore Hospital and Medical Center, Bronx, NY
    • Division of Neuropathology, Department of Pathology, Montefiore Hospital and Medical Center, 111 E 210th St, Bronx, NY 10467
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  • Asao Hirano

    MD
    1. Division of Neuropathology, Department of Pathology, Montefiore Hospital and Medical Center, Bronx, NY
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Abstract

Sacral anterior horns were examined with special reference to the Onufrowicz nucleus in 3 patients with Werdnig-Hoffman disease, 2 with healed anterior poliomyelitis, and 1 who had undergone amputation of both legs above the knee. None of these patients showed symptoms of either urethral or anal sphincter disturbances. The Onufrowicz nucleus of the second sacral anterior horn appeared normal in all the patients examined, though the lateral portion of that horn and the medial nuclear group of the third sacral segment were frequently involved. These findings support the view that the Onufrowicz nucleus may be innervating the external sphincter muscle of the urethra and the anus.

Ancillary