Treatment of elevated intracranial pressure in reye syndrome

Authors

  • Dr. Doris A. Trauner,

    MD, Corresponding author
    1. Department of Neurology, University of California Medical Center, San Diego, CA
    • Department of Neurology, University of California Medical Center, AID 8151, San Diego, CA 92103
    Search for more papers by this author
  • Frederick Brown,

    MD
    1. Department of Neurology, University of California Medical Center, San Diego, CA
    2. Departments of Pediatrics and Neurosurgery, University of Chicago Pritzker School of Medicine, Chicago, IL
    Search for more papers by this author
  • Edward Ganz,

    MD
    1. Department of Neurology, University of California Medical Center, San Diego, CA
    2. Departments of Pediatrics and Neurosurgery, University of Chicago Pritzker School of Medicine, Chicago, IL
    Search for more papers by this author
  • Peter R. Huttenlocher

    MD
    1. Department of Neurology, University of California Medical Center, San Diego, CA
    2. Departments of Pediatrics and Neurosurgery, University of Chicago Pritzker School of Medicine, Chicago, IL
    Search for more papers by this author

Abstract

Continuous intraventricular monitoring of intracranial pressure appears to be a useful aid in the management of patients with Reye syndrome, especially those in stage 3 or 4 coma, in which the mortality rate remains high. Elevations in intracranial pressure can be treated promptly and before the patient shows clinical signs of deterioration. Careful attention to adequate airway care is essential. The use of paralytic agents to reduce pressure secondary to muscle movement is useful. The minimum dose of mannitol required can be carefully titrated, and sudden pressure changes can be combated by release of small amounts of cerebrospinal fluid.

Ancillary