Recurrent seizures induced by cortical iron injection: A model of posttraumatic epilepsy

Authors

  • Dr. L. James Willmore,

    MD, Corresponding author
    1. Neurology Service, Veterans Administration Hospital, and the Departments of Neurology, Neurosurgery, and Neuroscience, University of Florida College of Medicine, Gainesville, FL
    • Neurology Service (127), Veterans Administration Hospital, Gainesville, FL 32602
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  • George W. Sypert,

    MD
    1. Neurology Service, Veterans Administration Hospital, and the Departments of Neurology, Neurosurgery, and Neuroscience, University of Florida College of Medicine, Gainesville, FL
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  • John B. Munson PhD

    1. Neurology Service, Veterans Administration Hospital, and the Departments of Neurology, Neurosurgery, and Neuroscience, University of Florida College of Medicine, Gainesville, FL
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Abstract

A single injection of 5 or 10 μl of ferrous or ferric chloride into rat or cat sensorimotor cortex resulted in chronic recurrent focal paroxysmal electroencephalographic discharges as well as behavioral convulsions and electrical seizures. Iron-filled macrophages, ferruginated neurons, and astroglial cells surrounded the focus of seizure discharge. Recurrent focal epileptiform discharges caused by cortical injection of iron salts suggests that the development of human posttraumatic epilepsy may depend, in part, on neurochemical alterations induced by the principal metallic ions found in whole blood.

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