Palatal myoclonus and denervation supersensitivity in the central nervous system

Authors

  • Dr Fumisuke Matsuo MD,

    Corresponding author
    1. Department of Neurology, University of Utah College of Medicine, Salt Lake City, UT
    2. University of Iowa College of Medicine, Iowa City, IA
    • Department of Neurology, University of Utah Medical Center, 50 N Medical Dr. Salt Lake City, UT 84132
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  • Ernest T. Ajax MD

    1. Department of Neurology, University of Utah College of Medicine, Salt Lake City, UT
    2. University of Iowa College of Medicine, Iowa City, IA
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Abstract

We postulate that palatal myoclonus after infarction of the brainstem or cerebellum, or both, is the manifestation of denervatio supersensitivity secondary to lesions involving the dentatorubroolivary system. Two cases of our own and 31 from the English and French literature were analyzed in order to determine the delay between the occurrence of presumed anatomical lesions and the recognition of palatal myoclonus. The intervals varied from 2 to 49 months with the median between 10 and 11 months. The natural history of palatal myoclonus following brainstem infarction seemed consistent with the hypothesis.

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