Torsion dystonia in israel

Authors

  • Amos D. Korczyn MD, MSc,

    Corresponding author
    1. Sackler School of Medicine, Tel Aviv University, and Beilinson Hospital, Petah Tikva, Hadassah University Hospital, Jerusalem, Barzilai Hospital, Ashkelon, Ichilov Hospital, Tel Aviv, Israel
    2. Temple University Hospital, Philadelphia, PA
    • Department of Physiology and Pharmacology, Tel Aviv University Medical School, Ramat Aviv, Israel
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  • Esther Kahana MD,

    1. Sackler School of Medicine, Tel Aviv University, and Beilinson Hospital, Petah Tikva, Hadassah University Hospital, Jerusalem, Barzilai Hospital, Ashkelon, Ichilov Hospital, Tel Aviv, Israel
    2. Temple University Hospital, Philadelphia, PA
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  • Nelly Zilber D ès Sc,

    1. Sackler School of Medicine, Tel Aviv University, and Beilinson Hospital, Petah Tikva, Hadassah University Hospital, Jerusalem, Barzilai Hospital, Ashkelon, Ichilov Hospital, Tel Aviv, Israel
    2. Temple University Hospital, Philadelphia, PA
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  • Max Streifler MD,

    1. Sackler School of Medicine, Tel Aviv University, and Beilinson Hospital, Petah Tikva, Hadassah University Hospital, Jerusalem, Barzilai Hospital, Ashkelon, Ichilov Hospital, Tel Aviv, Israel
    2. Temple University Hospital, Philadelphia, PA
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  • Raphael Carasso MD,

    1. Sackler School of Medicine, Tel Aviv University, and Beilinson Hospital, Petah Tikva, Hadassah University Hospital, Jerusalem, Barzilai Hospital, Ashkelon, Ichilov Hospital, Tel Aviv, Israel
    2. Temple University Hospital, Philadelphia, PA
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  • Milton Alter MD

    1. Sackler School of Medicine, Tel Aviv University, and Beilinson Hospital, Petah Tikva, Hadassah University Hospital, Jerusalem, Barzilai Hospital, Ashkelon, Ichilov Hospital, Tel Aviv, Israel
    2. Temple University Hospital, Philadelphia, PA
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Abstract

A country-wide search for idiopathic torsion dystonia (ITD) in Israel between 1969 and 1975 revealed 42 patients (41 Jewish and 1 Druze Arab). Prevalence of ITD per million population, age-adjusted to the United States population in 1970, was 10.8 in the total Jewish population (22.0 among Jews of European extraction contrasted with 1.5 among Jews with Afro-Asian forebears). Among Europeans, the highest prevalence was among Jews from Eastern Europe.

The average age-adjusted annual incidence rates per million population were 0.43 in the total Jewish population, 0.98 in the Europeans, and 0.11 in the Afro-Asians. Among the 40 patients for whom familial data were available, the majority of cases (26) were sporadic. The other 14 belonged to four unrelated European families, all of Russian-Polish origin. The pattern of inheritance in these four families fits an autosomal dominant model with incomplete penetrance.

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