Thrombotic stroke associated with elevated plasma factor VIII

Authors

  • Kenneth S. Kosik MD,

    1. Departments of Neurology, Medicine, and Biochemistry and Pharmacology, Tufts—New England Medical Center and Tufts University School of Medicine, Boston, MA
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  • Bruce Furie MD

    Corresponding author
    1. Departments of Neurology, Medicine, and Biochemistry and Pharmacology, Tufts—New England Medical Center and Tufts University School of Medicine, Boston, MA
    • Division of Hematology-Oncology, Department of Medicine, Tufts—New England Medical Center, 171 Harrison Ave, Boston, MA 02111
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Abstract

A previously healthy 43-year-old woman developed bilateral middle cerebral artery occlusion, thrombocytopenia, and multiple thrombi of arteries in the spleen. No underlying cause of her thrombotic disease was detected except for a factor VIII level that was elevated fivefold. An etiological relationship between the cerebral occlusive disease and elevated factor VIII level is suggested. We recommend that factor VIII levels be assayed in patients with stroke when an underlying disorder is not identified.

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