C-6 Glioma Growth in Rats: Suppression with a β-Adrenergic Agonist and a Phosphodiesterase Inhibitor

Authors

  • Ewa Chelmicka-Schorr MD,

    Corresponding author
    1. Department of Neurology, The University of Chicago, Pritzker School of Medicine, Chicago, IL
    • Department of Neurology, The University of Chicago, 950 E 59th St, Chicago, IL 60637
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  • Barry G. W. Arnason MD,

    1. Department of Neurology, The University of Chicago, Pritzker School of Medicine, Chicago, IL
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  • Sidney J. Holshouser MSc

    1. Department of Neurology, The University of Chicago, Pritzker School of Medicine, Chicago, IL
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Abstract

Rat C-6 glioma possesses a β-adrenergic receptor which, when activated, raises intracellular levels of cyclic adenosine monophosphate (cAMP) in cultured C-6 glioma cells. The present study shows that growth of C-6 glioma is suppressed in rats treated with the β-adrenergic agonist isoproterenol. Addition of papaverine, a cAMP phosphodiesterase inhibitor, to the treatment schedule augments this effect. Pharmacological agents that elevate intracellular cAMP levels may retard the growth of neural tumors in vivo.

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