Selective fiber vulnerability in acute ischemic neuropathy
Article first published online: 7 OCT 2004
Copyright © 1982 American Neruological Association
Annals of Neurology
Volume 11, Issue 2, pages 147–154, February 1982
How to Cite
Parry, G. J. and Brown, M. J. (1982), Selective fiber vulnerability in acute ischemic neuropathy. Ann Neurol., 11: 147–154. doi: 10.1002/ana.410110207
- Issue published online: 7 OCT 2004
- Article first published online: 7 OCT 2004
- Manuscript Accepted: 7 JUN 1981
- Manuscript Revised: 4 JUN 1981
- Manuscript Received: 16 MAR 1981
- Supported by the Muscular Dysrrophy Association and by Grant NS-08075 from the National Institutes of Health.
To study the relationship between fiber size and vulnerability to ischemia, we produced partial infarction of the proximal posterior tibial nerve of Wistar rats by injecting arachidonic acid into the ipsilateral femoral artery. In the resulting lesion degenerating fibers were concentrated in the center of the nerve. Distal to the infarct, surviving myelinated and unmyelinated fibers were evenly distributed throughout both fascicles. Smaller myelinated fibers (<6μm in diameter) were more severely depleted than larger ones (>6μm). Unmyelinated fibers were reduced in number in proportion to or to a greater extent than myelinated fibers. These findings demonstrate that large myelinated fibers are relatively less vulnerable to peripheral nerve ischemia than smaller fibers, and do not support the contention that unmyelinated fibers are inherently resistant to acute ischemia.