Brief Communications and Case Report

Primary cerebellopontine progressive multifocal leukoencephalopathy diagnosed premortem by cerebellar biopsy

  1. H. Royden Jones Jr. MD1,4,*,
  2. E. Tessa Hedley-Whyte MD4,5,
  3. Stephen R. Freidberg MD2,
  4. Joseph E. Kelleher Jr. MD3,
  5. John Krolikowski MD5,†

Article first published online: 7 OCT 2004

DOI: 10.1002/ana.410110218

Issue

Annals of Neurology

Annals of Neurology

Volume 11, Issue 2, pages 199–202, February 1982

Additional Information

How to Cite

Jones, H. R., Hedley-Whyte, E. T., Freidberg, S. R., Kelleher, J. E. and Krolikowski, J. (1982), Primary cerebellopontine progressive multifocal leukoencephalopathy diagnosed premortem by cerebellar biopsy. Ann Neurol., 11: 199–202. doi: 10.1002/ana.410110218

Author Information

  1. 1

    Department of Neurology, Lahey Clinic Medical Center, 41 Mall Rd, Box 541, Burlington, MA 01805

  2. 2

    Department of Neurosurgery, Lahey Clinic Medical Center, 41 Mall Rd, Box 541, Burlington, MA 01805

  3. 3

    Department of Allergy and Dermatology, Lahey Clinic Medical Center, 41 Mall Rd, Box 541, Burlington, MA 01805

  4. 4

    Harvard Medical School, New England Deaconess Hospital, 185 Pilgrim Rd, Boston, MA 02215

  5. 5

    Department of Pathology, New England Deaconess Hospital, 185 Pilgrim Rd, Boston, MA 02215

  1. †

    Department of Pathology, Lawrence Memorial Hospital, 170 Governors Ave, Medford, MA 02155

*Department of Neurology, Lahey Clinic Medical Center, 41 Mall Rd, Box 541, Burlington, MA 01805

Publication History

  1. Issue published online: 7 OCT 2004
  2. Article first published online: 7 OCT 2004
  3. Manuscript Accepted: 28 MAY 1981
  4. Manuscript Revised: 8 MAY 1981
  5. Manuscript Received: 18 FEB 1981

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Abstract

A subacute progressive cerebellar brainstem syndrome developed in a patient with systemic lupus erythematosus in remission. Cerebellar biopsy documented the diagnosis of progressive multifocal leukoencephalopathy (PML). Data from this patient and 10 others in the literature emphasize the need to consider this diagnosis when ataxia develops in any patient with underlying malignancy, chronic infection, or other disease that involves immunological incompetence. Although the ataxic form of PML is not of nosological relevance, early diagnosis may eventually hav therapeutic importance.

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