Age differences in intercorrelations between regional cerebral metabolic rates for glucose

Authors

  • Dr Barry Horwitz PhD,

    Corresponding author
    1. Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20205
    • National Institute on Aging, Building 10, Room 12S-235, 9000 Rockville Pike, Bethesda, MD 20205
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  • Ranjan Duara MD,

    1. Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20205
    Current affiliation:
    1. Division of Nuclear Medicine, Department of Radiology, Mt. Sinai Medical Center, University of Miami School of Medicine, Miami Beach, FL 33140
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  • Stanley I. Rapoport MD

    1. Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20205
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Abstract

Patterns of cerebral metabolic intercorrelations were compared in the resting state in 15 healthy young men (ages 20 to 32 years) and 15 healthy elderly men (ages 64 to 83 years). Controlling for whole-brain glucose metabolism, partial correlation coefficients were determined between pairs of regional cerebral metabolic rates for glucose determined by positron emission tomography using [18F]fluorodeoxyglucose and obtained in 59 brain regions. Compared with the young men, the elderly men had fewer statistically significant correlations, with the most notable reductions observed between the parietal lobe regions, and between the parietal and frontal lobe regions. These results suggest that cerebral functional interactions are reduced in healthy elderly men.

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