Low CSF protein concentration in idiopathic pseudotumor cerebri

Authors

  • Dr Vijay Chandra MD, PhD,

    Corresponding author
    1. Neuroepidemiology Branch, Intramural Research Program, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD
    • Neuroepidemiology Branch, NINCDS, NIH Federal Building, Rm 804, 7550 Wisconsin Avenue, Bethesda, MD 20892
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  • Srinath N. Bellur MD,

    1. Department of Neurology, University of Illinois at Chicago, Chicago, IL
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  • Robert J. Anderson MPH, PhD

    1. Epidemiology-Biometry Program, School of Public Health, University of Illinois at Chicago, Chicago, IL
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Abstract

An inverse relationship between the cerebrospinal fluid (CSF) opening pressure and the corresponding protein value was found for patients with idiopathic pseudotumor cerebri who underwent their first lumbar puncture (LP) prior to the initiation of therapy. This relationship provides evidence for a pressure-dependent bulk flow absorption for CSF and also suggests that patients with high CSF pressures will have low CSF protein concentration.

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