Effect of generalized spike-and-wave discharge on glucose metabolism measured by positron emission tomography

Authors

  • Rachel F. Ochs MD,

    1. Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, Montréal, Québec, H3A 2B4, Canada
    Current affiliation:
    1. Neurological Test Center, Northwestern Memorial Hospital, 303E Superior, Chicago, IL 60611
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  • Dr. Pierre Gloor MD, PhD,

    1. Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, Montréal, Québec, H3A 2B4, Canada
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  • Jane L. Tyler MD,

    1. Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, Montréal, Québec, H3A 2B4, Canada
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  • Tina Wolfson PhD,

    1. Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, Montréal, Québec, H3A 2B4, Canada
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  • Keith Worsley PhD,

    1. Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, Montréal, Québec, H3A 2B4, Canada
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  • Frederick Andermann MD,

    1. Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, Montréal, Québec, H3A 2B4, Canada
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  • Mirko Diksic PhD,

    1. Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, Montréal, Québec, H3A 2B4, Canada
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  • Ernst Meyer PhD,

    1. Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, Montréal, Québec, H3A 2B4, Canada
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  • Allan Evans PhD

    1. Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, Montréal, Québec, H3A 2B4, Canada
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Abstract

Positron emission tomography was used to study the cerebral metabolic rate for glucose (CMRGlc) in 7 adult patients with generalized spike-and-wave activity in the electroencephalogram. No consistent changes were seen in the CMRGlc. There was a slight trent toward an increased CMRGlc in 2 patients with primary generalized epilepsy, while in the 5 other patients with minor deviations from this condition or with secondary generalized epilepsy, the CMRGlc was unaffected by spike-and-wave activity or was below the normal range. Neither the amount of spike-and-wave activity in the EEG nor the presence of clinically evident absence seizures appeared to influence the CMRGlc. Therefore, we conclude that neuronal activity underlying spike-and-wave discharge does not seem to require increased glucose utilization.

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