Positron emission tomography in Shy-Drager syndrome

Authors

  • Mohit H. Bhatt MD, DM,

    1. Belzberg Laboratory of Clinical Neuroscience, Division of Neurology, University of British Columbia, and UBC/TRIUMF PET Program, Vancouver, Canada
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  • Barry J. Snow MBChB, FRACP,

    1. Belzberg Laboratory of Clinical Neuroscience, Division of Neurology, University of British Columbia, and UBC/TRIUMF PET Program, Vancouver, Canada
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  • W. R. Wayne Martin MD, FRCPC,

    1. Belzberg Laboratory of Clinical Neuroscience, Division of Neurology, University of British Columbia, and UBC/TRIUMF PET Program, Vancouver, Canada
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  • Sandra Cooper RN,

    1. Belzberg Laboratory of Clinical Neuroscience, Division of Neurology, University of British Columbia, and UBC/TRIUMF PET Program, Vancouver, Canada
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  • Dr Donald B. Calne DM, FRCP, FRCPC

    Corresponding author
    1. Belzberg Laboratory of Clinical Neuroscience, Division of Neurology, University of British Columbia, and UBC/TRIUMF PET Program, Vancouver, Canada
    • Department of Medicine, Division of Neurology, 2211, Wesbrook Mall, Vancouver, British Columbia, V6T 1W5, Canada
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Abstract

We studied the nigrostriatal dopaminergic pathway in 3 patients with Shy-Drager syndrome, by using positron emission tomography and [18F]6-fluoro-1-dopa to determine whether their parkinsonism correlated with impaired functional integrity of the presynaptic nigrostriatal pathway. One patient had short duration of disease, mild parkinsonism, and a normal positron emission tomographic scan, suggesting pathological changes functionally distal to the nigrostriatal pathway. Two patients with longer duration of disease had more severe parkinsonism and reduced [18F]6-fluoro-1-dopa uptake, suggesting impaired nigrostriatal dopaminergic function with progression of Shy-Drager syndrome.

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