Basic Mechanisms of Oxidative Damage
Oxygen radicals as key mediators in neurological disease: Fact or fiction?
Article first published online: 8 OCT 2004
Copyright © 1992 The American Neurological Association
Annals of Neurology
Supplement: Role of Iron and Oxidant Stress in the Normal and Parkinsonian Brain
Volume 32, Issue Supplement S1, pages S10–S15, 1992
How to Cite
Halliwell, B. (1992), Oxygen radicals as key mediators in neurological disease: Fact or fiction?. Ann Neurol., 32: S10–S15. doi: 10.1002/ana.410320704
- Issue published online: 8 OCT 2004
- Article first published online: 8 OCT 2004
A free radical is any species capable of independent existence that contains one or more unpaired electrons. Free radicals and other reactive oxygen species are frequently proposed to be involved in the pathology of several neurological disorders. Criteria for establishing such involvement are presented. Development of new methods for measuring oxidative damage should enable elucidation of the precise role of reactive oxygen species in neurological disorders.