Human positron emission tomographic [18F]Fluorodopa studies correlate with dopamine cell counts and levels

Authors

  • B. J. Snow MD,

    1. Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Search for more papers by this author
  • I. Tooyama MD, PhD.,

    1. Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, Canada
    2. Institute of Molecular Neurobiology, Shiga University of Medical Science, Otsu, Seta, Japan
    Search for more papers by this author
  • Dr. E. G. McGeer PhD.,

    Corresponding author
    1. Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, British Columbia, Canada
    2. Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, Canada
    • Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 1Z3
    Search for more papers by this author
  • T. Yamada MD, PhD.,

    1. Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, Canada
    Search for more papers by this author
  • D. B. Calne MD,

    1. Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Search for more papers by this author
  • H. Takahashi MD,

    1. Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Search for more papers by this author
  • H. Kimura MD, PhD.

    1. Institute of Molecular Neurobiology, Shiga University of Medical Science, Otsu, Seta, Japan
    Search for more papers by this author

Abstract

Postmortem counts of dopaminergic cell densities in the substantia nigra (5 subjects) and striatal levels of dopamine (DA) and its metabolites (6 subjects) were determined on 1 parkinsonian (PD), 3 progressive supranuclear palsy (PSP), 1 amyotrophic lateral sclerosis, and 1 Alzheimer's case who had been positron emission tomography scanned with 6-[18F]fluorodopa during life. [18F]Fluorodopa uptake rate constants, which presumably depend on the number of functioning striatal DA terminals, were strictly proportional to cell densities (significant correlation with zero intercept) and also correlated significantly with striatal DA levels but with an intercept indicating greater losses of DA than of terminals in PSP and PD. Postmortem data on 6 PD, 1 PSP, and 9 neuronally normal controls substantiated the significant correlation between cell counts and DA levels, with the latter being the more depressed in pathological cases.

Ancillary