Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium?

Authors

  • T. Tsuda MD, PhD,

    1. From the Division of Neurology, Department of Medicine, and the Center for Research in Neurodegenerative Diseases, University of Toronto, Toronto
    Search for more papers by this author
  • R. Lopez BSc,

    1. Wein Center for Alzheimer Disease at Mt. Sinai Medical Centre, University of Miami, Miami Beach, FL
    Search for more papers by this author
  • E. A. Rogaeva PhD,

    1. From the Division of Neurology, Department of Medicine, and the Center for Research in Neurodegenerative Diseases, University of Toronto, Toronto
    2. National Research Centre for Mental Health, Academy of Medical Sciences, Moscow, Zagorodnoe, Russia
    Search for more papers by this author
  • M. Freedman MD,

    1. Behavioral Neurology Program and Rotman Research Institute, Baycrest Centre for Geriatric Care; Department of Medicine (Neurology), Mount Sinai Hospital and University of Toronto
    Search for more papers by this author
  • E. Rogaev PhD,

    1. From the Division of Neurology, Department of Medicine, and the Center for Research in Neurodegenerative Diseases, University of Toronto, Toronto
    2. National Research Centre for Mental Health, Academy of Medical Sciences, Moscow, Zagorodnoe, Russia
    Search for more papers by this author
  • D. Drachman MD,

    1. Department of Neurology, University of Massachusetts Medical Center, Worcester
    Search for more papers by this author
  • D. Pollen MD,

    1. Department of Neurology, University of Massachusetts Medical Center, Worcester
    Search for more papers by this author
  • J. Haines PhD,

    1. Molecular Neurogenetics Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA
    Search for more papers by this author
  • Y. Liang MD,

  • D. R. Crapper McLachlan MD,

    1. From the Division of Neurology, Department of Medicine, and the Center for Research in Neurodegenerative Diseases, University of Toronto, Toronto
    Search for more papers by this author
  • R. Duara MD,

    1. Wein Center for Alzheimer Disease at Mt. Sinai Medical Centre, University of Miami, Miami Beach, FL
    Search for more papers by this author
  • P. St George-Hyslop MD, FRCP(C)

    Corresponding author
    1. From the Division of Neurology, Department of Medicine, and the Center for Research in Neurodegenerative Diseases, University of Toronto, Toronto
    • Division of Neurology, Department of Medicine, and the Center for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada M5S1A8
    Search for more papers by this author

Abstract

Allele frequencies for polymorphisms in the aplipoprotein E and the apolipoprotein CII genes were determined in subjects of Ashkenazi Jewish origin with lateonset Alzheimer's disease and in unaffected control subjects from the same ethnic group. A significant association was observed between late-onset Alzheimer's disease and the ε4 (112Cys→Arg) allele of apolipoprotein E; however, no association was detected with apolipoprotein CII. These results suggest that the association with ε4 is probably not due to linkage disequilibrium.

Ancillary