Concentrations of amyloid β protein in cerebrospinal fluid of patients with alzheimer's disease



Deposition of fibrillar amyloid β protein (Aβ) is increased in brains of patients with Alzheimer's disease. Concentrations of Aβ were measured in cerebrospinal fluid with an enzyme-linked immunosorbent assay in 10 neurological patients free from neurodegenerative disease, 28 patients with Parkinson's disease, and 18 patients with probable Alzheimer's disease. Levels of Aβ in cerebrospinal fluid were not significantly different among these groups. This observation suggests that concentrations of soluble Aβ in cerebrospinal fluid as measured in this study do not reflect the amount of fibrillar, aggregated Aβ in the brain of patients with Alzheimer's disease.